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Thrombocytopenia - drug induced

Definition

Thrombocytopenia is any disorder in which there are not enough platelets. Platelets are cells in the blood that help the blood clot. A low platelet count makes bleeding more likely.

When drugs or medications are the causes of a low platelet count, it is called drug-induced thrombocytopenia.

See also: Thrombocytopenia

Alternative Names

Drug-induced thrombocytopenia

Causes, incidence, and risk factors

Drug-induced thrombocytopenia occurs when certain drugs or medications destroy platelets (the cells that help blood clot) or interfere with the body's ability to make enough of them.

There are two types of drug-induced thrombocytopenia:

• Immune
• Nonimmune

If a drug causes your body to produce antibodies, which seek and destroy your platelets, the condition is called drug-induced immune thrombocytopenia. Heparin, a blood thinner, is probably the most common cause of drug-induced immune thrombocytopenia.

If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia. Chemotherapy drugs and a seizure medication called valproic acid may lead to this problem.

Other drugs that cause drug-induced thrombocytopenia include:

• Diabetes drugs taken by mouth
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Penicillin
• Quinidine
• Quinine
• Ranitidine
• Some drugs used to treat arthritis conditions
• Sulfonamides
• Water pills (diuretics)

Symptoms

Decreased platelets may cause:

• Bleeding when you brush your teeth
• Easy bruising
• Pinpoint red spots on the skin (petechiae)
• Other abnormal bleeding

Signs and tests

See: Thrombocytopenia

Treatment

The first step in treating this type of low platelet count is to stop using the drug that may be causing the problem.

For people who have life-threatening bleeding, treatments may include:

• Immunoglobulin therapy (IVIG) given through a vein
• Plasma exchange (plasmapheresis)
• Platelet transfusions

Support Groups

Expectations (prognosis)

Complications

Bleeding can be life threatening if it occurs in the brain or other organs.

A pregnant woman who has antibodies to platelets may pass the antibodies to the baby in the womb.

Calling your health care provider

Call your healthcare provider if you have unexplained bleeding or bruising.

References

Visentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin North Am. 2007;21:685-696.

Warkentin TE. Thrombocytopenia due to platelet destruction and hypersplenism. In: Hoffman R, Benz Jr. EJ, Shattil SJ, Furie B, Silberstein LE, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone;2008:chap 140.