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We provide a comprehensive continuum of cancer services, including prevention, outreach, diagnostic, treatment and support services delivered by our highly skilled staff with compassion and care.
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The Center for Women & Children's Health is a hub for supporting women's and children's individual healthcare needs. The center provides support, research and unmatched patient-centered care.
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Emergency and Trauma Services is the only Level I Trauma Center in the area and serves as the tertiary referral center for medical care in East Tennessee, serving Knox County and 21 surrounding counties.
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The Heart Lung Vascular Institute brings together expertise in clinical care, teaching and research. Patients receive exceptional healthcare combined with patient-centered care.
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Hemoglobin C disease
Definition
Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.
Alternative Names
Clinical hemoglobin C
Causes, incidence, and risk factors
Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by problem with a gene called beta globin.
The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.
Symptoms
Most people do not have symptoms. Occasionally, jaundice may occur. Some persons with this disease may develop gallstones that require treatment.
Signs and tests
Physical examination may show an enlarged spleen.
Tests that may be done include:
- Complete blood count
- Peripheral blood smear
- Blood hemoglobin
Treatment
Usually no treatment is needed. Folic acid supplementation may help your body produce normal red blood cells and improve the symptoms of the anemia.
Support Groups
Expectations (prognosis)
People with hemoglobin C disease can expect to lead a normal life.
Complications
Complications include anemia, gall bladder disease, and enlargement of the spleen.
Calling your health care provider
Call your health care provider if you have symptoms of hemoglobin C disease.
Prevention
Genetic counseling may be appropriate for high-risk couples who wish to have a baby.
References
Steinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 167.
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