The Brain and Spine Institute is made up of experts in the field of neuroscience in order to bring patients the best healthcare in East Tennessee for a full range of neurological diseases and disorders.
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The Brain and Spine Institute is made up of experts in the field of neuroscience in order to bring patients the best healthcare in East Tennessee for a full range of neurological diseases and disorders.
We provide a comprehensive continuum of cancer services, including prevention, outreach, diagnostic, treatment and support services delivered by our highly skilled staff with compassion and care.
The Center for Women & Children's Health is a hub for supporting women's and children's individual healthcare needs. The center provides support, research and unmatched patient-centered care.
Emergency and Trauma Services is the only Level I Trauma Center in the area and serves as the tertiary referral center for medical care in East Tennessee, serving Knox County and 21 surrounding counties.
The Heart Lung Vascular Institute brings together expertise in clinical care, teaching and research. Patients receive exceptional healthcare combined with patient-centered care.

Puberty is the time during which sexual and physical characteristics mature. Precocious puberty is when these body changes happen earlier than normal.
Pubertas praecox
Puberty usually begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. Some African American girls may start puberty earlier, around age 9.
The exact age a child enters puberty depends on a number of factors, including family history, nutrition, and gender.
Often there is no clear cause for precocious puberty, but some cases are due to changes in the brain, genetic problems, or certain tumors that release hormones. These conditions include:
In girls, precocious puberty is when any of the following develop before age 8:
Some evidence suggests that it may be normal for these changes to occur as early as age 7 in Caucasian girls and age 6 in African-American girls.
In boys, precocious puberty is when any of the following develop before age 9:
Blood hormone levels, CT scan of the brain or of the abdomen and MRI of the brain or of the abdomen are often used to diagnose the problem.
Medications can stop the release of sexual hormones. Some tumors need to be removed with surgery.
Children who go through puberty too early may not reach their full height because growth stops too early.
Children with early sexual development are more likely to have psychological and social problems. Children and adolescents generally want to be the same as their peers, and early sexual development can make them appear different. This can result in self-esteem problems, depression, acting out at school and home, and abuse of alcohol and illegal substances.
See your health care provider if:
Styne DM, Grumbach MM. Puberty: Ontogeny, Neuroendocrinology, Physiology, and Disorders. In: Kronenberg HM, Melmed, S, Polonsky KS, Larsen PR, eds. . 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008: chap 24.
Williams Textbook of Endocrinology
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