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Macroamylasemia
Definition
Macroamylasemia is the presence of an abnormal substance called macroamylase in the blood.
Causes, incidence, and risk factors
Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.
Most people with macroamylasemia have no serious underlying disorder, but the condition has been associated with:
- Celiac disease
- Lymphoma
- Monoclonal gammopathy
- Ulcerative colitis
Symptoms
Macroamylasemia does not cause symptoms.
Signs and tests
A blood test will show high levels of amylase. However, macroamylasemia can be confused with acute pancreatitis, which also causes high levels of amylase in the blood.
Macroamylasemia can be diagnosed by measuring amylase levels in the urine. Urine levels of amylase are low. (Urine amylase levels are high in patients with acute pancreatitis.)
Treatment
Support Groups
Expectations (prognosis)
Complications
Calling your health care provider
Prevention
References
Owyang C. Pancreatitis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 147.
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