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Chronic thyroiditis (Hashimoto’s disease)

Definition

Chronic thyroiditis is swelling (inflammation) of the thyroid gland that often results in reduced thyroid function (hypothyroidism).

Alternative Names

Hashimoto's thyroiditis; Chronic lymphocytic thyroiditis; Autoimmune thyroiditis

Causes

Chronic thyroiditis or Hashimoto's disease is a common thyroid gland disorder. It can occur at any age, but is most often seen in middle-aged women. It is caused by a reaction of the immune system against the thyroid gland.

The disease begins slowly. It may take months or even years for the condition to be detected. Chronic thyroiditis is most common in women and in people with a family history of thyroid disease. It affects between 0.1% and 5% of all adults in Western countries.

Hashimoto's disease may, in rare cases, be related to other endocrine (hormonal) disorders caused by the immune system. Hashimoto's disease can occur with adrenal insufficiency and type 1 diabetes. In these cases, the condition is called type 2 polyglandular autoimmune syndrome (PGA II).

Less commonly, Hashimoto's disease occurs as part of a condition called type 1 polyglandular autoimmune syndrome (PGA I), along with:

• Adrenal insufficiency (poor function of the adrenal glands)
• Fungal infections of the mouth and nails
• Hypoparathyroidism (underactive parathyroid gland)

Symptoms

• Constipation
• Difficulty concentrating or thinking
• Dry skin
• Enlarged neck or presence of goiter
• Fatigue
• Hair loss
• Heavy and irregular periods
• Intolerance to cold
• Mild weight gain
• Small or shrunken thyroid gland (late in the disease)

Other symptoms that can occur with this disease:

• Joint stiffness
• Weight gain (unintentional)
• Swelling of the face

Note: There may be no symptoms.

Exams and Tests

Laboratory tests to determine thyroid function include:

• Free T4 test
• Serum TSH
• T3
• Thyroid autoantibodies:
  • Antithyroid peroxidase antibody
  • Antithyroglobulin antibody

Imaging studies are generally not needed to diagnose Hashimoto's thyroiditis.

This disease may also change the results of the following tests:

• Complete blood count
• Serum prolactin
• Serum sodium
• Total cholesterol

Treatment

A lack of thyroid hormone may develop. You may receive thyroid hormone replacement therapy (levothyroxine) if your body is not producing enough of the hormone. Or, you may receive it if you have signs of mild thyroid failure (such as elevated TSH). This condition is also known as subclinical hypothyroidism.

If there is no evidence of thyroid hormone deficiency, you may just need to be seen regularly by a health care provider.

Outlook (Prognosis)

The outcome is usually very good. The disease stays stable for years. If it does slowly progress to thyroid hormone deficiency (hypothyroidism), it can be treated with thyroid replacement therapy.

Possible Complications

This condition can occur with other autoimmune disorders. In rare cases, thyroid cancer may develop.

When to Contact a Medical Professional

Call your health care provider if you develop symptoms of chronic thyroiditis.

Prevention

There is no known way to prevent this disorder. Being aware of risk factors may allow earlier diagnosis and treatment.

References

Ladenson P, Kim M. Thyroid. In: Goldman L and Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders; 2007:chap 244.

Brent GA, Larsen PR, Davies TF. Hypothyroidism and thyroiditis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 12.

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