The Brain and Spine Institute is made up of experts in the field of neuroscience in order to bring patients the best healthcare in East Tennessee for a full range of neurological diseases and disorders.
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The Brain and Spine Institute is made up of experts in the field of neuroscience in order to bring patients the best healthcare in East Tennessee for a full range of neurological diseases and disorders.
We provide a comprehensive continuum of cancer services, including prevention, outreach, diagnostic, treatment and support services delivered by our highly skilled staff with compassion and care.
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The Heart Lung Vascular Institute brings together expertise in clinical care, teaching and research. Patients receive exceptional healthcare combined with patient-centered care.

Wrinkles are creases in the skin.
Most wrinkles are associated with aging changes in skin. Aging of the skin and related structures (hair and nails) is a natural process. Nothing can be done to decrease the rate of skin aging, but many environmental factors will increase the rate.
Frequent exposure to sunshine results in premature skin wrinkling and increased pigmentation (liver spots). It also increases the likelihood of skin cancer. Exposure to cigarette smoke is another environmental factor that increases wrinkling of the skin.
Besides wrinkles, other skin changes may include liver spots (pigmented areas). The hair and nails also change with aging, including graying of the hair, hair loss, and brittleness of the nails.
Common causes of wrinkles include:
To minimize skin wrinkling, stay out of the sun as much as possible. When you are outside, wear protective clothing and use sunscreen. If you smoke, stop smoking.
Wrinkles are not usually a concern unless they occur at an early age. Consult your health care provider if you think that your skin is becoming excessively wrinkled at an early age. A referral to a dermatologist or plastic surgeon is sometimes appropriate.
Your doctor may ask detailed questions about your wrinkles, such as:
A detailed examination of the skin will be performed. If wrinkles are accompanied by a skin lesion that has changed in appearance, diagnostic tests may include a skin lesion biopsy.
Tretinoin (Retin-A) or creams containing alpha-hydroxy acids may be recommended, but these aren't guaranteed to help.
Chemical peels or laser resurfacing are very effective options for early wrinkles.
Botulinum toxin (Botox) may be used to correct some of the wrinkles associated with overactive facial muscles.
Some patients may choose plastic surgery for age-related wrinkles (for example, a facelift).
Habif TM. Light-related diseases and disorders of pigmentation. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2009:chap 19.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).