Clinical Trials Directory

Are you interested in taking part in a clinical trial? Our Clinical Trials Directory includes all active clinical trials at The University of Tennessee Medical Center.

Moving Medical Knowledge Forward, Every Day

Doctors and researchers at The University of Tennessee Medical Center work together diligently. Our goal is to discover new and better ways to find and treat disease. We do this through various research projects and clinical trials.

Research projects at the medical center help move forward medical knowledge. The National Institutes of Health and related agencies fund researchers on our campus to bring the best of medical care to East Tennessee. Plus, our physicians provide clinical trial opportunities for our patients. We make them readily available to those who seek new medications and treatment.

Our research teams work closely with researchers throughout the University of Tennessee system as well as others throughout the nation.

The University of Tennessee Medical Center brings together outstanding patient care, challenging clinical training and stimulating research – all on one campus.

Find a Clinical Trial


Natera — BESPOKE CRC study for patients who have been diagnosed with State II or III CRC and will be tested with Signatera.

Xilis- Microorgano Sphere (MOS) Drug screen to lead care (MODEL) Precision oncology pilot trial in colorectal cancer.

Dysfunctional CVADs

Chiesi Ready 1 CUSA-081-HEM-01 — A Phase 3, Randomized, Double-Blind, Active and Placebo-Controlled Study on the use of CUSA-081 for Dysfunctional Central Venous Access Devices (CVADs).

Follicular Lymphoma

Epizyme/Parexel — A Phase 1b/3 Double-Blind, Randomized, Placebo-Controlled, 3-Stage, Biomarker Adaptive Study of Tazemetostat in Combination with Lenalidomide Plus Rituximab vs Placebo in Combination with Lenalidomide Plus Rituximab in Subjects with Relapsed/Refractory Follicular Lymphoma.


ECOG EA2197- Phase II/III trial to compare neoadjuvant Gemcitabine/Cisplatin and adjuvant Gemcitabine/Cisplatin in Stage T2 vs T3 incidental Gallbladder Cancer

Head and Neck

PDS Biotech/iQVIA — A Phase II, Open-Label, Multi-Center Study of PDS0101 (ImmunoMAPK-RDOTAP/HPV-16 E6 & E7 peptides) and Pembrolizumab (KEYTRUDA) Combination Immunotherapy as a First Line Treatment in Patients with Recurrent and/or Metastatic Head and Neck Cancer and High-risk Human Papillomavirus-16 (HPV16) Infection.

Hodgkin Lymphoma

None at this time.


Trillium TTI-622-01 — A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-622 in Patients with Advanced Relapsed or Refractory Lymphoma or Myeloma.

Seattle Genetics SGN35-032 — Dual cohort, open label, Phase 2 study of BV and CHP (A+CHP) in the frontline treatment of patients with PTCL with less than 10% CD30 expression.

ONO Pharma- An open-label phase II trial to investigate the efficacy and safety for patients with relapsed or refractory Primary Central Nervous System Lymphoma


Amgen Herpetic Infection 20130193 — A post-marketing prospective cohort study of Melanoma patients treated with Imlygic (Talimogene Laherparepvec) in clinical practice to characterize the risk of Herpetic infection among patients, close contacts, and health care providers, and long-term safety in treated patients.

Pfizer C4221016 — A phase 3, randomized, double-blind study of Encorafenib and Binimetinib plus Pembrolizumab versus placebo plus Pembrolizumab in previously untreated BRAF V600E/K mutation-positive participants with unresectable or metastatic melanoma.

Regeneron- A Phase 3 trial of Fianlimab (REGN-3767, Anti-LAG 3) + Cemiplimab vs. Pembrolizumab in patients with previously untreated unresectable locally advanced or metastatic melanoma.

Natera Bespoke- Immunotherapy monitoring clinical trial

Merkel Cell

ECOG EA6174- a Phase III study of adjuvant Pembrolizumab vs Observation in surgically treated Merkel Cell.

Non-Small Cell Lung Cancer

Merck MK3475-867 — A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA NSCLC (KEYNOTE-867).

Mersana/GOG3048 — Phase 1b, first in human, dose escalation and expansion study of XMT-1536 in patients with solid tumors likely to express NaPi2b.

Iovance- A Phase 2 Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Metastatic Non-Small-Cell Lung Cancer.

Alliance A151216- adjuvant lung cancer enrichment marker identification and sequencing trial

Alliance A081801- integration of immunotherapy into adjuvant therapy for resected non small cell lung cancer

ECOG EA5163/S1709- a randomized, Phase III study of first line immunotherapy alone or in combination with chemotherapy in induction/maintenance or post progression in advanced non-squamous non-small cell lung cancer with immunobiomarker signature-driven analysis

ECOG E4512- a component of the Alchemist trial-a randomized Phase III trial for surgically resected early stage non- small cell lung cancer: Crizotinib versus observation for patients with tumors harboring the anaplastic lymphoma kinase (ALK) Fusion protein

Ovarian Cancer

None at this time.

Pancreatic Cancer

ECOG EA2185- a study comparing the clinical impact of pancreatic cyst surveillance programs

Alliance A021806- a Phase 3 trial of perioperative versus adjuvant chemotherapy for resectable pancreatic cancer.

XBiotech- A phase I/II , double-blind, placebo-controlled trial examining XB2001 (anti-IL-1 True Human antibody) in combination with ONIVYDE + 5-FU/LV (+folinic acid) in advanced pancreatic cancer.

Prostate Cancer

Lilly CYCLONE 3- a  Phase 3, global, multicenter study to evaluate Abemaciclib in combination with abiraterone and prednisone for the treatment of patients with high-risk metastatic hormone-sensitive prostate cancer.

Ratio- A Phase 0 study of the Pharmacokinetics and Biodistribution of PSMA-targeted (In-111)-labeled Trillium  compounds with and without PTI-122 in patients with metastatic prostate cancer to inform future phase 1 dosing with (Ac-225)-Trillium-PSMA Radionuclide Therapy.

Renal Cancer

MK-6482-012 — An Open-label, Randomized Phase 3 Study of Immune and Targeted Combination Therapies, as first line treatment in Participants with Advanced ccRCC.

Alliance A031704- This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body.

Small Cell Lung Cancer

Merck MK7339-013 — A phase 3 study of Pembrolizumab in combination with concurrent chemoradiation therapy followed by Pembrolizumab with or without Olaparib, compared to concurrent chemoradiation therapy followed by placebo in participants with newly diagnosed treatment naïve limited-stage small cell lung cancer.

Cutaneous Squamous Cell Carcinoma

Regeneron Case — A prospective survivorship cohort study of adult patients with cutaneous squamous cell carcinoma undergoing treatment with Cemiplimab.

Castle Biosciences CBI-2019-cSCC-PVS-001 — Prospective Validation of a Gene Expression Assay to Predict the Risk of Recurrence Disease in Cutaneous Squamous Cell Carcinoma.

Alliance A091802- a Phase II, randomized trial of Avelumab plus Cetuximab vs. Avelumab alone in advance cutaneous squamous cell.

Urothelial Carcinoma

Alliance A032001— a Phase III randomized trial of maintenance Cabozantinib and Avelumab vs maintenance Avelumab after first-line platinum-based chemotherapy in patients with metastatic urothelial cancer.

Janssen Sunrise 2- A Phase 3, Multi-Center, randomized study evaluating efficacy of TAR-200 in combination with Cetrelimab vs concurrent chemoradiotherapy in patients with MIBC who are not receiving radical cystectomy.

Seattle Genetics RC48G001- A Phase 2 Mulit-cohort, open-label, multi-center clinical study evaluating the efficacy and safety of Disitamab Vedotin (RC48-ADC) in subjects with HER-2 expressing locally advanced unresectable or metastatic urothelial carcinoma.

Acute Ischemic Stroke

Genentech- Tenecteplase in patients with Acute Ischemic Stroke. A pharmacokinetic study.


UCB BioPharma- A Phase 2A study to evaluate the efficacy, safety, and tolerability of oral UCB0599 in study participants with early Parkinson’s Disease.

None at this time.

Kidney Transplantation

Incyte- Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety and Pharmacokinetics of Parsaclisib in Participants with Primary AIHA.


Prothena- A Phase 3, Multicenter, Open-Label, Single-Arm, Efficacy and Safety Study of Birtamimab Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis.

Kidney Transplantation

VUMC Apollo — Long term Kidney Transplantation Outcomes Network

Incyte- Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety and Pharmacokinetics of Parsaclisib in Participants with Primary AIHA.


Prothena- A Phase 3, Multicenter, Open-Label, Single-Arm, Efficacy and Safety Study of Birtamimab Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis.


Ohio Health- Prospective study of Mean Arterial Blood Pressure Augmentation in the Treatment of Spinal Cord Injuries (MAP study).

UPITT Pamper- To determine the effect of the prehospital infusion during air transport of 2 units of AB plasma on 30 day mortality in patients with hemorrhagic shock as compared to conventional care. Data Collection Only.

University of Pittsburgh LITES Network (TOWAR)- Type O Whole blood and assessment of Age during prehospital Resuscitation (TOWAR) Trial. Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.

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